Xgeva 120mg injections | Tablets | Blueberrypharmaceuticals


XGEVA

Xgeva 120mg injection is a trade name of denosumab and which belongs to type of monoclonal antibody. This drug is classified as a “bone-modifying agent”, it works as a RANK ligand (RANKL) inhibitor. Xgeva 120mg injection which attach and repairs only certain cells in the body and help to protect healthy cells from destroy.

INDICATION

Xgeva 120mg injection is indicated for the treatment of Osteoporosis occur in men and women (menopause stage) (end of menopause/ change of life), whose have severe problem of fractures increased or who failed to other medication of osteoporosis.In adults and some adolescents with giant cell tumor of bone which cannot cured with surgery / surgery is not possible is treated with Xgeva 120mg injection.

MECHANISM OF ACTION :

Denosumab is decided to target RANKL (RANK ligand), a protein which act as the main signal to help bone removal/resorption. Some of the bone loss conditions, RANKL overcome the body's natural defense against bone eradication. 
Prevention of the RANKL/RANK interplay prevents osteoclast formation, function, and survival, hence reducing bone resorption and raising bone mass and vitality in both cortical and trabecular bone. 

DRUG – DRUG INTERACTION :

  • No formal drug-drug interaction with denosumab during trials.
  • When interacting with some anticancer drug, orthopedic drugs, vaccines will lead to risk of adverse effects can be increased.

    SIDE EFFECTS :

    Common side effects :

    • Fatigue
    • Muscle weakness
    • Phosphorus level reduced in blood.
    • Nausea

    Less common side effects :

    • Dyspnea
    • Hypocalcemia
    • Cough
    • Arthralgia 
    • Limb pain
    • Eczema 
    • Headache

    PRECAUTIONS
    Xgeva 120mg injection may improve the negative effects of immuno-suppressants. Especially the risk for severe infections may be raised. Inform your doctor of any immuno-suppressive drugs you early consume. 
    Not to receive any type of vaccination without your doctor's consultation while admonishing denosumab. 
    Prior to start treatment with denosumab, consult with your doctor about any other regimens you are using (including over-the-counter drugs, vitamins, or herbal remedies). Not to take aspirin or products containing aspirin unless your doctor permits this. 
    Any plan to become pregnant prior to starting this treatment, consult with doctor before the treatment because use in pregnancy only if benefit to mother outweighs risk to fetus). 

CONTRAINDICATIONS :

Xgeva is contraindicated in :

Hypocalcemia
Pregnancy
Hypersensitivity.

PRECAUTION :

The Xgeva 120mg belongs to category C which has no sufficient data in pregnant women to convey any drug analog risk for adverse development outcomes 
The drug in pregnant women is contraindicated for use because it may cause serious risk to the fetus.

For More Information

Call Us : +91-97890 77748

Domain :  info@blueberrypharma.com



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