Alecensa 150mg tablets | Apple pharmaceuticals

ALECENSA 150MG


Description :

Alecensa 150mg belongs to class of second generation oral drug which specifically prevents the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase.
Alecensa is a prescription drug which used under the guidance of doctor. It is part used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes proliferation of NSCLC cells.

Indication :

Alecensa 150mg is used for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC).

Image result for lung cancer

Dosage Modification 

Non- Small Cell Lung Cancer
The usual dose is 600mg PO BID until disease progression or unacceptable
Renal impairment patients dose is 450mg orally twice daily
Alecensa is administrated with food.

Mechanism :

In nonclinical studies, Alectinib inhibits ALK phosphorylation and ALK-mediated activation of the downstream indicating proteins STAT3 and AKT anddecreases tumor cell viability in multiple cell lines harbouring ALK fusions, elaborations, or activating mutations.

Precaution :

Embryo-fetal toxicity:

depends on data from animal studies and its pharmacological action, Alecensa can cause fetal harm when administered to pregnant women.
While Alecensa administration, Symptomatic bradycardia may have observed; control heart rate and blood pressure regularly
Alecensa may causes Severe myalgia and elevated CPK resulted; advise patients to report any unexplained muscle pain, tenderness, or weakness;
Renal impairment occurred during Alecensa treatment; incidence of Grade ≥3 renal impairment was 1.7%, of which 0.5% were fatal events.

Missed Dose

If the patient vomits after taking a dose of ALECENSA or missed to take a dose, then should not to take an extra dose, but to take the next dose at the regular time, skip the missed dose.

Storage :

Store at below 30℃
Store the drug in original container

For More Information : 

Call us :  +91-9987711567
Mail to :  applepharmaceutical@gmail.com




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